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Provides care for anyone who has a mental, addictive, and emotional disorders. Psychiatry and Psychology department provides services including:

- Addiction Treatment Center: Comprehensive car including assessment of alcohol or other substance use problem, mental health concerns, and medical status, treatment for addictions and mental health concerns

- Inpatient psychiatric units: Acute care unit, medical and geriatric psychiatry unit, mood disorder unit, child, adolescent and family treatment unit, and adult transitions program

- Mayo Clinic Depression Center: Offers comprehensive, evidence-based evaluation, and treatment

- Pain Rehabilitation Center

The department integrates with the medical and surgical teams, such as:

- Bariatric surgery

- Behavioral Neurology

- Children's

- Comprehensive Cancer Center

- Endocrinology

- Executive Health Program

- Gastroenterology and Hepatology

- General Internal Medicine

- Neurology

- Neurosurgery

- Nicotine Dependence Center

- Physical Medicine and Rehabilitation

- Primary Care

- Sleep Medicine

- Transgender and Intersex Specialty Care Clinic

- Transplant Center

- Women's Health